5 edition of Molecular Mechanism of Muscle Contraction found in the catalog.
Molecular Mechanism of Muscle Contraction
May 1, 1988
Written in English
Advances in Experimental Medicine and Biology
|The Physical Object|
|Number of Pages||742|
While the sliding-filament theory of muscle contraction (1, 2) is universally accepted, the detailed mechanism of transduction of chemical energy, derived from ATP hydrolysis, into mechanical work remains the object of intense vitro motility assays have established that the relative motion of thick and thin filaments in the sarcomere is generated by myosin heads (), which undergo Cited by: Sliding Filament Mechanism in Muscle Contraction: Fifty Years of Research covers the history of the sliding filament mechanism in muscle contraction from its discovery in by H.E. Huxley through and including modern day research. Chapters include topics in dynamic X-ray diffraction, electron microscopy, muscle mechanisms.
The Molecular Mechanism of Muscle Contraction Kenneth C. Holmes Max Planck Institute for Medical Research Heidelberg Germany e-mail [email protected] Introduction The sliding filament hypothesis (Hanson and Huxley ; Huxley and Niedergerke ), now 50 years old, provides the basis for modern muscle research. The discovery. Work performed with differentiated contractile smooth muscle tissue over the last two decades has made clear that covalent modification of myosin by phosphorylation of the kDa myosin light chains is a significant mode of regulation of contractile activity in smooth muscle, particularly in regard to the generation of phasic contractions and the initial development of tonic by:
Sliding Filament Mechanism of Muscle Contraction• Muscle contraction occurs by a sliding filament mechanism.• When action potential travels along the muscle fiber, sarcoplasmic reticulum release large quantities of calcium ions that rapidly surround the myofibrils.• Energy is needed for the contractile process to proceed. Ca 2+ SENSITIZATION MECHANISM AND CONTRACTION OF SMOOTH MUSCLE. In addition to the Ca 2+-dependent activation of MLC kinase, the state of myosin light chain phosphorylation is further regulated by MLC phosphatase [aka myosin phosphatase (1, 4, 9, 11–16)], which removes the high-energy phosphate from the light chain of myosin to promote smooth muscle relaxation ().Cited by:
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Molecular and Physiological Mechanisms of Muscle Contraction: Medicine & Health Science Books @ hor: Jean Emile Morel. This item: Molecular Mechanisms of Smooth Muscle Contraction (Molecular Biology Intelligence Unit) Set up a giveaway.
Get fast, free delivery with Amazon Prime. Prime members enjoy FREE Two-Day Delivery and exclusive access to music, movies, TV shows, original audio series, and Kindle books. Thoroughly researched using experimentation and re-examination of all previously published evidence, Molecular and Physiological Mechanisms of Muscle Contraction is a carefully crafted treatise and revision of previous conceptions of muscle contraction.
It presents detailed descriptions of new, previously unpublished data and hybrids recent findings with the standard Huxley model. Thoroughly researched using experimentation and re-examination of all previously published evidence, Molecular and Physiological Mechanisms of Muscle Contraction is a carefully crafted treatise and revision of previous conceptions of muscle contraction.
More specifically, most experiments on muscle contraction mechanisms have been designed, carried out and interpreted on the basis of the Huxley's and the Huxley-Simmons' contraction models, as well as the kinetic scheme of actomyosin ATPase; but the molecular mechanism of contraction still remains to be a matter for debate and speculation.
Authors: Rall, Jack A. Usually dispatched within 3 to 5 business days. Usually dispatched within 3 to 5 business days. This book describes the evolution of ideas relating to the mechanism of muscular contraction since the discovery of sliding filaments in Brand: Springer-Verlag New York.
Contrary to their expectation, however, the basic mechanisms of motility have been revealed solely by investigations on vertebrate skeletal muscles, since a monumental discovery of Szent-Gyorgyi and his coworkers in the early s that muscle contraction results from the interaction between two different contractile.
Publisher Summary. This chapter describes the analysis of the polymorphism of the myosin crossbridge and relates it to the Lymn–Taylor crossbridge cycle. Myosin from muscle (myosin II) consists of two long polypeptide chains (heavy chains) combined with four light chains.
In cross-striated muscle, the tails of the molecules pack together Cited by: A muscle contraction can be explained by the cycle of molecular events that take place between actin and myosin filaments.
In a single cycle, a myosin head binds to an actin filament, performs a power stroke, and then releases. The whole process is called the mechanism of muscle contraction and it can be summarized in three steps: (1) A message travels from the nervous system to the muscular system, triggering chemical reactions.
(2) The chemical reactions lead to the muscle fibers reorganizing themselves in a way that shortens the muscle--that’s the contraction. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy.
Commonalities and contrasts among these three tissue types are highlighted. ISBN: OCLC Number: Description: xv, pages: illustrations ; 26 cm: Contents: 1. Introduction: historical account and overview Materials and methods Analysis and characteristics of some major biophysical, enzymological and physiological phenomena in an intact unit cell during contraction (isometric and isotonic) Mechanism of Muscular Contraction.
This book describes the evolution of ideas relating to the mechanism of muscular contraction since the discovery of sliding filaments in An amazing variety of experimental techniques have been employed to investigate the mechanism of muscular contraction and relaxation.5/5(1). Start studying Molecular Mechanisms of Muscle Contraction.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. The Mechanism of Muscle Contraction: Sarcomeres, Action Potential, and the Neuromuscular Junction - Duration: Professor Dave Explainsviews Before this symposium, I have organized muscle symposia five times, and published the proceedings: " Cross-bridge Mechanism in Muscle Contraction (University of Tokyo Press, ), "Contractile Mechanisms in Muscle" (plenum, ); "Molecular Mechanisms of Muscle Contraction" (plenum, ); "Mechanism of MyofIlament Sliding in Muscle.
The Molecular Mechanism of Muscle Contraction. The aim of this review is to summarize the current understanding of the cellular and molecular mechanisms responsible for muscle regeneration. In Author: Kenneth C.
Holmes. Muscle contraction is the activation of tension-generating sites within muscle fibers. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as when holding a heavy book or a dumbbell at the same position.
The termination of muscle contraction is followed by muscle relaxation, which is a. A muscle contraction can be explained by the cycle of molecular events that take place between actin and myosin filaments.
In a single cycle, a myosin head binds to an actin filament, performs a power stroke, and then releases. Note that for the two filaments to disconnect, the myosin head must bind to a fresh molecule of ATP. During the last decades we have seen a major revision of the immutable postulates underlying the molecular mechanisms of muscle contraction.
One of the best examples is the discovery of giant proteins widely distributed in nature from nematodes to by: 3.
Concluding Remarks on Molecular and Functional Aspects of Muscle Differentiation Smooth Muscle Mediators and Mechanisms of Activation of Contraction in Smooth Muscle The Transport Mechanisms by which Contraction Activating Extracellular Ca2+ Ions Enter Smooth Muscle Cells (Introductory Remarks)Book Edition: 1.The molecular events of muscle fiber shortening occur within the fiber’s sarcomeres (see Figure 3).The contraction of a striated muscle fiber occurs as the sarcomeres, linearly arranged within myofibrils, shorten as myosin heads pull on the actin filaments.During the last few years the basic features of the sliding-filament model of contraction in striated muscle have gained general *acceptance and it has been possible to concentrate attention on the detailed mechanism by which the relative sliding force between the actin and myosin filaments is devel- oped.
Anumber of observations have indicated in general outline how cross.